Clotilde POLICAR

Metals in Biology and Redox Homeostasis

Clotilde POLICAR

Clotilde POLICAR

Professor

Bioinorganic chemistryInorganic chemical biologyMimics of superoxide dismutasesIR-bio-imagingX-fluorescence bio-imaging

see https://ens-bic.fr/

Trained in organic, inorganic and physical chemistry, Clotilde Policar specialized in bio-inorganic chemistry. Professor at the Ecole Normale Supérieure—Paris Sciences et Lettres, since 2008, she has set up a group in bioinorganic chemistry and inorganic biological and cellular chemistry that works on the study of inorganic compounds in biological environments.

She is a member of the Société chimique de France and of the international society in biological inorganic chemistry SBIC and serves currently as its past president. She is a member of the Société Chimique de France.

She is currently the dean of sciences education at ENS-PSL.

Research Topics

Endogenous metals imaging in biological processes

Endogenous metals imaging in biological processes

While present at relatively low concentrations compared to organic species, endogenous metals are in…

Bio-active metal complexes and catalysis

Bio-active metal complexes and catalysis

We design metal-complexes as mimics of antioxidant metalloenzymes (catalases, superoxide dismutases)…

Metal-based probes

Metal-based probes

Re(CO)3 complexes are developed as multimodal probes to correlate fluorescence, IR-imaging and X-flu…

Professional experiences

2025-present: co-direction of a “grand programme” from PSL university (ChemCellState)
2025-present: co-direction of the research group METHROX in the CPCV UMR8228 lab
Oct-2021-Oct-2022: president elect of SBIC; Oct. 2022-Oct. 2024: president of SBIC ; Oct. 2024-Oct. 2026: past president of SBIC (international Society of Biological Inorganic Chemistry)
Since 2020: dean of the sciences education at the Ecole normale supérieure (ENS-PSL)
2019-2020: responsible of the two-year master programme in Chemistry and Life Science (parcours Chimie et sciences du vivant du master de chimie de Paris Centre)
2019-2021: elected member of the SBIC council
2017-2021: member of the editorial board of Journal of Inorganic Biochemistry
2016-2020: deputy director of the Institut de Chimie du CNRS (DAS, directrice adjointe science) in charge of interdisciplinarity, work in the MITI-CNRS (mission pour les initiatives transverses et l’interdisciplinarité)
2015-2017: member of the advisory board of Inorganic Chemistry (ACS)
2015-2020: deputy chair of the FrenchBIC  (French network in BioInorganic Chemistry, network of 25 laboratories)
2014-2020:  dean of the studies at the department of chemistry of ENS, co-responsible for the international relationships
2014-2023:  deputy director of the Research Unit Laboratoire des BioMolécules, UMR7203
2008: nomination as a professor at the ENS
2005-2008: associate professor, Paris-Sud 11 university (now Paris Saclay)
2005 (nov.): habilitation thesis, Paris-Sud 11 university (now Paris Saclay)
1996-2005: assistant professor, Paris-Sud 11 university (now Paris Saclay), Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO)

Education

  • 1995-1996: post-doctoral fellow, CEA, department of cellular and molecular biology, group of William Rutherford and Sun Un (Multifrequency high spin electron paramagnetic resonance (9.5 – 285 GHz), study of Mn(III)-Mn(IV) complexes mimicking the Oxygen Evolving Center of photosystem II).
  • 1992-1995: PhD under the supervision of Dr. Isabelle Artaud and Dr. Daniel Mansuy (Chemical modelling of the bimetallic active site of the metalloprotein manganese-peroxidase)
  • 1988-1992: Student in the chemistry department at ENS-Paris Saclay (élève normalienne)
  • 1991-1992: Graduate studies (DEA) in bioinorganic chemistry, Paris-Sud 11 university
  • 1990-1991: Agrégation de sciences physiques option chimie (highest diploma to become a high-school teacher)

Research Interests

Research interests

  • Bioinorganic chemistry— Inorganic chemical biology
  • Superoxide dismutase mimics (SOD mimics), superoxide, cellular models of oxidative stress, metal-based anti-oxidants
  • Metal-carbonyls as multimodal probes for imaging: IR-spectromicroscopy, micro X-ray fluorescence and classical fluorescence. Design as organelles trackers.
  • Metals in biology: intracellular detection,  metal imaging, metal distribution, metal speciation
  • Oxidative stress
  • Therapeutic applications of metal-based anti-oxidants

About a past project funded by ANR (nation research agency): https://www.ens.psl.eu/actualites/des-catalyseurs-bio-inspires-pour-lutter-contre-le-stress-oxydant

Awards, distinctions, scientific societies membership, and research contracts

· Co-recipient of the 2022 Fédération Gay-Lussac Prize 2022 awarded by the Institut de France and the French Académie des Sciences, on “Chemistry and Its Impact on Society”

· President elect (Oct21-Oct22), president (Oct22-Oct24) and then past president (Oct24-Oct26) of SBIC.

· Elected member of the international council of the SBIC in October 2019.

· Member of the Société chimique de France and of the FrenchBIC.

· Research contracts since 2008:
-ANR contracts (National Funding Agency) : two as a PI (CATMAN, 2020-2024 ; MAGIC, 2015-2021) ; four ANR contracts as a partner (MOBIDIC, PI P. Seksik (2022-2026) ; MnHFPELDOR, PI L. Tabares, 2012-2015, Take Care, PI M. Robert, 2011-13 ; Metabact, PI I. Artaud, 2011-13)
-CEFIPRA contract (France-India collaboration, PI), 2022-2025
-Qlife initiative: project MAIN (2021-2022) as PI (Mn-based Antioxidant evaluation in Inflammatory Epithelial Cells)
-Research contract as PI from FRM (Fondation pour la recherche médicale, Appels Pionniers de la recherche Etudes Physico-chimiques innovantes pour la biologie et la médecine- 2016-2020)
-Research fellowship from the Association François Aupetit (association of inflammatory bowel disease patients) obtained in 2015
-Paris-Sciences-Lettres research contract for research structuration (PI, 2014-15; three partners : ESPCI and Institut Curie)
-Paris-Sciences-Lettres pre-maturation fellowship (PI, 2015)
-CNRS-contract Interdisciplinary work (interface chemistry-physic-biology), support for risky research (2009)
-Young researcher grant (ACI jeune chercheur) (2005-08)
-Since 2008: more than 15 projects selected on synchrotron beamlines (SOLEIL, APS, Aladdin).

· 1997: first prize “Creation” from the French Ministry of Research for the project Le ticket d’Archimède (posters of popularisation of science in the Parisian Metro), project directed by C. Policar from 1995 to 1998.

Congratulations to our former PhD students (for their permanent positions)

CONGRATULATIONS to Paul Demay Drouhard (Oct. 2023) and Emilie Mathieu (Sept. 2021), for their CR-CNRS positions in Orleans and Toulouse respectively, Sarah Hostachy for her recruitment as a researcher at CEAEA-Grenoble (Sept. 2020), Koudedja Coulibaly and Martha Zoumpoulaki, for their recruitments at Air Liquide (Nov. 2021 and March 2022 respectively).