Projects

Outils hybrides chimiogénétiques pour l'imagerie haute résolution du zinc dans le cerveau

A new instrument is developed, installed and exploited at ENS – PSL in the CPCV laboratory, coupling very high-field NMR (900 MHz) with evolution of nuclear spins at low magnetic field. This instrument will be open to the local and national scientific communities in chemistry, structural biology and material sciences.

Consortium of experimental platforms in Chemistry, Physics and Biology at PSL University for the preparation and characterization of systems from the molecule to nanometric devices and living systems.

This project complements the equipment acquired in the frame of the Equipex IMF-NMR project by co-funding the purchase of two cryogenic probes on the 900 MHz spectrometer, optimized for proton and carbon-13 detection.

Nonlinearities and controlled masers in DNP and solution NMR

Assess the potential use of recently developed NMR techniques for kinetic analysis of CO2 release by monoethanolamine solutions in CO2 capture.

Improving NMR sensitivity of nuclei with ultrabroad linewidths and poor sensitivity

Instrumentation and theory development of NMR hyperpolarization methods

Innovative methodologies for drug screening using photo-CIDNP and long-lived states (LLS).

Novel applications of photo-CIDNP in drug discovery and structural modeling of protein-ligand complexes.

Investigating how molecular dynamics affects allosteric enzyme activation using experimental and computational methods.

Understanding the organization, dynamics and mechanics of NHEJ DNA repair condensates and their regulatory interactions.